Good paper and a solid piece of research. These videos are very important, they allow people to visualise exactly what is going on and potentially develop treatments. For example, they not only allow us to see the flap opening wide, but allow us to see that both yellow lengths of side chains appear to be very active during opening. Thus, if either the flap or these hydrophilic lengths could be interfered with using a drug they could impede the molecule. Well done.

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